Semax

Semax Research Peptide

Semax is a synthetic, heptapeptide analog of adrenocorticotropic hormone (ACTH), engineered to investigate neurotrophic, neuroprotective, and cognitive modulation pathways, particularly BDNF/TrkB signalling, antioxidant enzyme regulation, and cerebral blood flow dynamics. It has become a high-interest compound in preclinical stroke, neurodegeneration, and stress-resilience research due to its stability, blood–brain barrier permeability, and multimodal neuromodulatory profile. This Semax research peptide is supplied as a lyophilised solid to ensure stability, purity, and reproducibility in laboratory and investigative settings.

Supplied in lyophilised (freeze-dried) form to preserve stability.

What is the Semax Research Peptide?

Semax (C₃₄H₄₈N₁₀O₁₁, MW: 772.80 g/mol) is a 7-amino-acid peptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro, modified with C-terminal amidation for enhanced protease resistance and CNS bioavailability [Ashmarin IP et al., Bull Exp Biol Med 2009; 147(4):411–415; DOI: 10.1007/s10517-009-0545-1]. Unlike unlicensed nootropic formulations, the Semax research peptide from NovaVitality is provided exclusively for in vitro, ex vivo, and preclinical research — not for human or veterinary use.

🔬 Note: Semax is registered in Russia as a prescription neuroprotectant (Semax®), but this RUO material is unformulated, preservative-free, and intended solely for mechanistic neuroscience and cerebrovascular research.

Scientific Identifiers

Usage and Reconstitution

The Semax research peptide is supplied freeze-dried for stability. For experimental protocols, reconstitute using:
✅ Sterile bacteriostatic water (0.9% benzyl alcohol in 0.9% NaCl), or
✅ Sterile saline (0.9% NaCl) — preferred for in vivo CNS studies (minimises irritation).

⚠️ Critical Handling Notes:
– Highly soluble — typically dissolves fully with gentle swirling (no warming or sonication needed).
– Avoid acetic acid — may reduce stability in long-term storage (Pro-rich sequences are acid-labile).
– Filter through a 0.22 µm PVDF syringe filter for intranasal or ICV studies.

Post-Reconstitution Storage:
– Short-term: 2–8°C for ≤7 days
– Long-term: Aliquot and store at −80°C (≤5 freeze–thaw cycles tolerated — Semax is highly stable in solution)

📌 For full protocol, download our [Semax Reconstitution & Handling Guide].

🛒 Recommended reconstitution accessories will be auto-added to cart → Adjust before checkout.

Semax Research Peptide: Key Investigational Pathways

Semax is actively studied for its multimodal neuromodulatory and neuroprotective effects. Key research applications include:

• Neurotrophic & Neuroprotective Signalling
  Investigated in:
  → Ischaemic stroke models (MCAO in rats; infarct volume, neurological deficit scoring)
  → Primary cortical neurons exposed to OGD (oxygen-glucose deprivation; LDH, MAP2 staining)
  → BDNF/TrkB/p75NTR expression (qPCR, Western blot, ELISA)
• Antioxidant & Metabolic Adaptation
  Explored via:
  → Superoxide dismutase (SOD), catalase, and glutathione peroxidase activity assays
  → Mitochondrial respiration (Seahorse XF Analyzer in neuronal cultures)
  → Nrf2 nuclear translocation (immunofluorescence, EMSA)
• Cerebrovascular & Cognitive Modulation
  Studied in:
  → Laser Doppler flowmetry for cerebral blood flow (CBF) in conscious rodents
  → Morris water maze and novel object recognition (NOR) for spatial/episodic memory
  → EEG/fMRI for network connectivity (default mode network modulation)
• Stress Response & HPA Axis Modulation
  Evaluated in:
  → Chronic unpredictable stress (CUS) models (corticosterone, CRH mRNA)
  → Fear conditioning and extinction paradigms
  → Microglial activation (Iba1⁺ morphology, IL-1β/TNF-α)

⚠️ All accessories (syringes, filters, vials) are for laboratory use only — not medical devices.

Why Order Semax from NovaVitality?

• 🔬 Batch-certified purity: Every lot includes full Certificate of Analysis (CoA) — HPLC, MS (MALDI-TOF), endotoxin (<0.5 EU/mg), residual solvents
• 🇬🇧 UK-based & compliant: MHRA-aligned documentation, GMP-adjacent handling, discreet tracked shipping (next-day available)
• 📚 Research-first ethos: No nootropic or cognitive-enhancement claims — full technical & protocol support
• 🛡️ RUO integrity: Meets expectations under MHRA GMP Guide, FDA 21 CFR 1271, EU GMP Annex 1
• 💬 Expert support: Get guidance on intranasal dosing, ischaemia models, or BDNF ELISA optimisation

Legal and Safety Information

NovaVitality supplies Semax strictly for laboratory research, assay development, and educational purposes (RUO).

❌ This product is not approved by the MHRA, FDA, EMA, or any regulatory authority for:
→ Human use
→ Veterinary use
→ Diagnostic use
→ Therapeutic, nootropic, or supplement use

⚠️ Critical Responsibilities for Researchers:
– Use only under approved institutional biosafety protocols
– Comply with local ethics oversight (e.g., AWERB for in vivo work)
– Maintain full chain-of-custody documentation
– Do not compound, dispense, or administer to living subjects

🔒 NovaVitality disclaims all liability for unauthorised or off-label use. By purchasing, you affirm compliance with all applicable laws and institutional policies.

Ready to Advance Neuroprotective Pathway Research?

📦 [Bacteriostatic Water]
💉 [Research Syringes]
📄 [Semax Storage & Stability Datasheet]