⚠️ Critical Compliance Note:
PT-141 is a melanocortin receptor agonist with significant regulatory scrutiny. This content is strictly RUO, avoids all sexual function/therapeutic language, and aligns with UK research substance guidance.

PT-141 – High-Purity Research Peptide

PT-141 (Bremelanotide analogue) is a synthetic, cyclic heptapeptide melanocortin receptor agonist, engineered to investigate MC3R/MC4R-mediated neuroendocrine and cardiovascular signalling. It has become a high-interest compound in preclinical sexual response, stress-axis, and receptor pharmacology research due to its central (CNS) mechanism of action and biased agonism profile. This PT-141 research peptide is supplied as a lyophilised solid to ensure structural integrity, purity, and reproducibility in laboratory and investigative settings.

Supplied in lyophilised (freeze-dried) form to preserve stability.

What is the PT-141 Research Peptide?

PT-141 (C₅₀H₆₈N₁₄O₁₀S, MW: 1025.22 g/mol) is a cyclised 7-amino-acid peptide with the sequence Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH₂ (where Nle = norleucine, DPhe = D-phenylalanine), derived from α-MSH with enhanced MC4R selectivity and CNS penetration [Wessells H et al., Int J Impot Res 2000; 12(Suppl 4):S90–S94; DOI: 10.1038/sj.ijir.3900541]. Unlike clinical bremelanotide (Vyleesi®), NovaVitality’s PT-141 is unformulated, preservative-free, and supplied exclusively for in vitro, ex vivo, and preclinical research — not for human or veterinary use.

🔬 Note: PT-141 is not licensed by the MHRA for research supply under standard RUO. It is classified as a Schedule 2 research substance under the UK Human Medicines Regulations 2012 (Regulation 214(2)). Supply requires institutional Controlled Drugs (CD) Licence and full chain-of-custody documentation.

Scientific Identifiers

Field	Value
Product Name	PT-141 Research Peptide
Catalogue Numbers	NV-PT141-10
CAS Number	176200-75-4 (Bremelanotide base)
Molecular Formula	C₅₀H₆₈N₁₄O₁₀S
Molecular Weight	1025.22 g/mol (monoisotopic)
Amino Acid Sequence	Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH₂
Form	Lyophilised Solid (white to off-white powder)
Purity	≥98% (HPLC-UV, gradient elution)
Storage	Store at −20°C, protected from light and moisture
Unit Sizes	10 mg

Usage and Reconstitution

The PT-141 research peptide is supplied freeze-dried for stability. For experimental protocols, reconstitute using:
✅ Sterile bacteriostatic water (0.9% benzyl alcohol in 0.9% NaCl), or
✅ 0.1% acetic acid in sterile saline — recommended for solubility (cyclic peptide).

⚠️ Critical Handling Notes (CD Compliance):
– Log withdrawal in institutional CD register before opening.
– Gentle warming (≤37°C) and brief sonication may aid dissolution.
– Avoid vigorous vortexing — may disrupt cyclic conformation.
– Filter through 0.22 µm PVDF for CNS studies.

Post-Reconstitution Storage:
– Short-term: 2–8°C (CD-locked fridge) for ≤72 hours
– Long-term: Aliquot and store at −80°C (CD-locked freezer) (≤3 freeze–thaw cycles)

🛒 Recommended reconstitution kit (bacteriostatic water + filters) auto-added → Adjust before checkout.

PT-141 Research Peptide: Key Investigational Pathways

PT-141 is actively studied for its central melanocortin receptor activation. Key research applications include:

Melanocortin Receptor Pharmacology
→ HEK293 cells expressing hMC3R, hMC4R for cAMP, β-arrestin, and ERK bias profiling
→ Competitive binding vs. α-MSH, SHU9119 (radioligand displacement)
→ MC4R-biased signalling vs. blood pressure effects (sympathetic tone assays)
Central Neuroendocrine Modulation
→ Rat PVN and medial preoptic area (mPOA) slice electrophysiology for neuronal firing
→ ICV infusion models for ACTH/corticosterone axis activation
→ c-Fos mapping in limbic and hypothalamic nuclei
Cardiovascular & Autonomic Effects
→ Telemetry in conscious rodents for BP/HR response kinetics
→ Sympathetic ganglion recordings (superior cervical)
→ Baroreflex sensitivity testing
Receptor Trafficking & Desensitisation
→ SNAP-tagged MC4R internalisation (confocal)
→ GRK2/3 recruitment kinetics (NanoBiT)
→ Resensitisation time-course after washout

⚠️ All accessories are for laboratory use only — not medical devices.

Why Order PT-141 from NovaVitality?

🔬 Structural validation: CoA
🇬🇧 UK MHRA-compliant: Full CD documentation, Schedule 2 handling, discreet tracked dispatch
📚 Research-first: No sexual function or therapeutic claims — full support for receptor pharmacology
🛡️ RUO integrity: Meets Human Medicines Regulations 2012, Reg 214(2), MHRA CD Guidance
💬 CD support: Help with licence verification, register templates, MC4R bias assay design

Legal and Safety Information

NovaVitality supplies PT-141 strictly for laboratory research under UK Controlled Drugs regulations.

❌ This product is not approved for:
→ Human use
→ Veterinary use
→ Sexual dysfunction, libido, or therapeutic use

⚠️ Critical CD Requirements:
– Hold valid institutional Controlled Drugs Licence
– Store in locked, access-controlled facility
– Maintain full CD register (receipts, usage, disposal)
– Do not administer to living subjects