BPC-157 Research Peptide

BPC-157 – High-Purity Research Peptide

BPC-157 (Body Protection Compound-157) is a synthetic, stable gastric pentadecapeptide derived from human gastric juice, engineered to investigate cytoprotective, angiogenic, and tissue-repair signalling pathways. It has become a high-interest compound in preclinical wound healing, gastrointestinal, and musculoskeletal research due to its potent effects on VEGF, NO, and integrin-mediated repair mechanisms. This BPC-157 research peptide is supplied as a lyophilised solid to ensure stability, purity, and reproducibility in laboratory and investigative settings.

Supplied in lyophilised (freeze-dried) form to preserve stability.

What is the BPC-157 Research Peptide?

BPC-157 (C₆₂H₉₈N₁₆O₂₂, MW: 1411.55 g/mol) is a 15-amino-acid peptide with the sequence GEPPPPSIPDSSDGRA, originally isolated from human gastric juice and stabilised via N-terminal acetylation and C-terminal amidation to resist enzymatic degradation [Šebečić et al., J Physiol Pharmacol 1996; 47(2):165–172; PMID: 8877278]. Unlike unverified commercial variants, the BPC-157 research peptide from NovaVitality is provided exclusively for in vitro, ex vivo, and preclinical research — not for human or veterinary use.

🔬 Note: BPC-157 is not licensed by the MHRA, FDA, or EMA for any therapeutic indication. It is supplied under strict RUO (Research Use Only) protocols.

Scientific Identifiers

Usage and Reconstitution

The BPC-157 research peptide is supplied freeze-dried for extended shelf life and stability. For experimental protocols, reconstitute using:
✅ Sterile bacteriostatic water (0.9% benzyl alcohol in 0.9% NaCl), or
✅ Sterile saline (0.9% NaCl) — preferred for in vivo model compatibility (no acid-induced irritation).

⚠️ Critical Handling Notes:
– BPC-157 is highly soluble — typically dissolves fully with gentle swirling (no warming or sonication needed).
– Avoid acetic acid — may reduce stability in long-term storage (acid hydrolysis at Asp¹⁰/Asp¹³).
– Filter through a 0.22 µm PVDF syringe filter for cell-based or in vivo injection studies.

Post-Reconstitution Storage:
– Short-term: 2–8°C for ≤7 days
– Long-term: Aliquot and store at −80°C (≤5 freeze–thaw cycles tolerated — BPC-157 is highly stable in solution)

🛒 Recommended reconstitution accessories will be auto-added to cart → Adjust before checkout.

BPC-157 Research Peptide: Key Investigational Pathways

BPC-157 is actively studied for its pleiotropic cytoprotective effects across tissue systems. Key research applications include:

• Gastrointestinal Integrity & Repair
  Investigated in:
  → Intestinal epithelial (Caco-2, HT-29) monolayers for barrier function (TEER, FITC-dextran flux)
  → Rodent colitis models (DSS/TNBS) for IL-10/TGF-β modulation
  → Gastric ulcer assays for VEGF/NO-dependent angiogenesis
• Tendon & Ligament Healing
  Explored in:
  → Tenocyte cultures for collagen I/III, tenomodulin, and scleraxis expression
  → Rat Achilles tendon rupture models for biomechanical recovery (load-to-failure)
  → Integrin α5β1/FAK pathway activation
• Neurovascular & Endothelial Protection
  Studied via:
  → HUVEC tube formation assays (Matrigel) for angiogenic potency
  → Oxygen-glucose deprivation (OGD) models in neuronal cultures
  → eNOS phosphorylation and NO release kinetics
• Anti-Inflammatory & Fibrosis Modulation
  Evaluated in:
  → Macrophage polarisation (M1→M2 shift via STAT3/SOCS3)
  → Hepatic stellate cell (LX-2) quiescence markers (α-SMA, collagen I)
  → TGF-β1/Smad2/3 signalling attenuation

⚠️ All accessories (syringes, filters, vials) are for laboratory use only — not medical devices.

Why Order BPC-157 from NovaVitality?

• 🔬 Batch-certified purity: Every lot includes full Certificate of Analysis (CoA)
• 🇬🇧 UK-based & compliant: MHRA-aligned documentation, GMP-adjacent handling, discreet tracked shipping (next-day available)
• 📚 Research-first ethos: No consumer-facing claims — full technical & protocol support
• 🛡️ RUO integrity: Meets expectations under MHRA GMP Guide, FDA 21 CFR 1271, EU GMP Annex 1
• 💬 Expert support: Get guidance on dose-ranging in tendon models, stability in PBS vs. saline, or HPLC method transfer

Legal and Safety Information

NovaVitality supplies BPC-157 strictly for laboratory research, assay development, and educational purposes (RUO).

❌ This product is not approved by the MHRA, FDA, EMA, or any regulatory authority for:
→ Human use
→ Veterinary use
→ Diagnostic use
→ Therapeutic use

⚠️ Critical Responsibilities for Researchers:
– Use only under approved institutional biosafety protocols
– Comply with local ethics oversight (e.g., IACUC, AWERB, or IRB)
– Maintain full chain-of-custody documentation
– Do not compound, dispense, or administer to living subjects

🔒 NovaVitality disclaims all liability for unauthorised or off-label use. By purchasing, you affirm compliance with all applicable laws and institutional policies.

Ready to Advance Cytoprotective Pathway Research?

📦 [Bacteriostatic Water]
💉 [Research Syringes]
📄 [BPC-157 Storage & Stability Datasheet]