DSIP (Delta Sleep Inducing Peptide)

DSIP Research Peptide

DSIP (Delta Sleep-Inducing Peptide) is a synthetic, nonapeptide originally isolated from human plasma, engineered to investigate endogenous sleep modulation, stress-axis regulation, and neuroendocrine homeostasis. It has become a high-interest compound in preclinical chronobiology, HPA axis, and opioid-receptor-adjacent signalling research due to its multimodal effects on slow-wave sleep, corticosterone rhythms, and antioxidant enzyme expression — without direct GABAergic or sedative mechanisms. This DSIP research peptide is supplied as a lyophilised solid to ensure stability, purity, and reproducibility in laboratory and investigative settings.

Supplied in lyophilised (freeze-dried) form to preserve stability.

What is the DSIP Research Peptide?

DSIP (C₄₁H₆₁N₁₁O₁₂, MW: 892.00 g/mol) is a 9-amino-acid peptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first characterised from porcine cerebral venous blood by Schally et al. (PNAS 1977). Unlike unverified commercial variants, NovaVitality’s DSIP is synthesised with native L-amino acids and validated by LC-MS and in vitro corticosterone modulation assays [Schally AV et al., Proc Natl Acad Sci USA 1977; 74(12):5498–5502; DOI: 10.1073/pnas.74.12.5498]. Supplied exclusively for in vitro, ex vivo, and preclinical research — not for human or veterinary use.

🔬 Note: Despite its name, DSIP’s effects on human sleep remain unproven. This RUO material is intended solely for mechanistic neuroendocrine and chronobiology research — not sleep aid or nootropic applications.

Scientific Identifiers

Usage and Reconstitution

The DSIP research peptide is supplied freeze-dried for stability. For experimental protocols, reconstitute using:
✅ Sterile bacteriostatic water (0.9% benzyl alcohol in 0.9% NaCl), or
✅ Sterile saline (0.9% NaCl) — preferred for in vivo CNS studies.

⚠️ Critical Handling Notes:
– Highly soluble — typically dissolves fully with gentle swirling (no warming or sonication needed).
– Avoid acetic acid — may reduce stability of Asp⁵/Glu⁹ residues over time.
– Filter through a 0.22 µm PVDF syringe filter for ICV or intranasal studies.

Post-Reconstitution Storage:
– Short-term: 2–8°C for ≤7 days
– Long-term: Aliquot and store at −80°C (≤5 freeze–thaw cycles tolerated — DSIP is highly stable in solution)

🛒 Recommended reconstitution accessories will be auto-added to cart → Adjust before checkout.

DSIP Research Peptide: Key Investigational Pathways

DSIP is actively studied for its neuroendocrine and chronobiological modulation. Key research applications include:

• HPA Axis & Stress Response
  Investigated in:
  → Rat hypothalamic explants for CRH release modulation
  → Plasma corticosterone rhythms (diurnal vs. stress-induced)
  → Glucocorticoid receptor (GR) nuclear translocation (immunofluorescence)
• Sleep Architecture & EEG Modulation
  Explored via:
  → Telemetry-implanted rodents (NREM/REM quantification, delta power)
  → In vitro thalamocortical slice oscillations (slow-wave activity)
  → Co-administration with orexin antagonists (synergy screening)
• Antioxidant & Metabolic Adaptation
  Studied in:
  → Mitochondrial ROS production (MitoSOX) in neuronal cultures
  → SOD, catalase, and glutathione peroxidase activity assays
  → Nrf2/Keap1 pathway modulation (Western blot, luciferase reporter)
• Opioid-System Adjacent Signalling
  Evaluated in:
  → [³⁵S]GTPγS binding assays (Gαi/o coupling in brain membranes)
  → Cross-tolerance studies with morphine (locomotor sensitisation)
  → β-endorphin secretion in AtT-20 cells

⚠️ All accessories (syringes, filters, vials) are for laboratory use only — not medical devices.

Why Order DSIP from NovaVitality?

• 🔬 Batch-certified purity: Every lot includes full Certificate of Analysis (CoA)
• 🇬🇧  UK-based & compliant: MHRA-aligned documentation, GMP-adjacent handling, discreet tracked shipping (next-day available)
• 📚 Research-first ethos: No “sleep aid” or “nootropic” claims — full technical & protocol support
• 🛡️ RUO integrity: Meets expectations under MHRA GMP Guide, FDA 21 CFR 1271, EU GMP Annex 1
• 💬 Expert support: Get guidance on ICV dosing, EEG study design, or corticosterone assay optimisation

Legal and Safety Information

NovaVitality supplies DSIP strictly for laboratory research, assay development, and educational purposes (RUO).

❌ This product is not approved by the MHRA, FDA, EMA, or any regulatory authority for:
→ Human use
→ Veterinary use
→ Diagnostic, therapeutic, sleep aid, or supplement use

⚠️ Critical Responsibilities for Researchers:
– Use only under approved institutional biosafety protocols
– Comply with local ethics oversight (e.g., AWERB for in vivo work)
– Maintain full chain-of-custody documentation
– Do not compound, dispense, or administer to living subjects

🔒 NovaVitality disclaims all liability for unauthorised or off-label use. By purchasing, you affirm compliance with all applicable laws and institutional policies.

Ready to Advance Chronobiology & Neuroendocrine Research?

📦 [Bacteriostatic Water]
💉 [Research Syringes]
📄 [DSIP Storage & Stability Datasheet]