Supplied for research purposes only. These peptides are laboratory reagents intended for qualified researchers and educational institutions. Not for human use, animal use, or clinical application.
π¬ RESEARCH USE ONLY β This product is strictly for laboratory research and educational purposes. Not for human or veterinary use.
Ipamorelin Research Peptide (10β40 mg, β₯98% purity, CAS 170903-93-8) β Selective GHSR-1a agonist for pulsatile GH secretion & receptor bias studies. RUO, CoA-backed, UK dispatch. Recommended products for reconstitution will be automatically added to the cart β Adjust quantities before checkout.
Ipamorelin is a synthetic, pentapeptide growth hormone secretagogue (GHS), engineered to investigate selective ghrelin receptor (GHSR-1a) activation, pulsatile GH release, and Somatotrope specificity without significant ACTH/cortisol or prolactin stimulation. It has become a high-value compound in preclinical endocrinology, receptor bias, and anabolic signalling research due to its clean pharmacological profile and high selectivity over other GHRPs (e.g., GHRP-6, Hexarelin). This Ipamorelin research peptide is supplied as a lyophilised solid to ensure structural integrity, purity, and reproducibility in laboratory and investigative settings.
Supplied in lyophilised (freeze-dried) form to preserve stability.
What is the Ipamorelin Research Peptide?
Ipamorelin (CββHββNβOβ , MW: 711.86 g/mol) is a 5-amino-acid peptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NHβ (where Aib = Ξ±-aminoisobutyric acid, D-2-Nal = D-2-naphthylalanine), designed for enhanced GHSR-1a affinity and protease resistance [Deghenghi R et al., Biopolymers 2001; 60(1):71β85; DOI: 10.1002/1097-0282(2001)60:1<71::AID-BIP1005>3.0.CO;2-Z]. Unlike non-selective GHRPs, Ipamorelin shows minimal activity at CRF or prolactin receptors, making it ideal for isolated GH pulse studies. Supplied exclusively for in vitro, ex vivo, and preclinical research β not for human or veterinary use.
π¬ Note: Ipamorelin is not licensed by the MHRA, FDA, or EMA. This RUO material is unformulated, preservative-free, and intended solely for ghrelin receptor pharmacology and GH secretagogue research.
Store at β20Β°C, protected from light and moisture
Unit Sizes
10 mg
Usage and Reconstitution
The Ipamorelin research peptide is supplied freeze-dried for stability. For experimental protocols, reconstitute using: β Sterile bacteriostatic water (0.9% benzyl alcohol in 0.9% NaCl), or β 0.1% acetic acid in sterile saline β recommended for solubility (hydrophobic D-2-Nal/D-Phe).
β οΈ Critical Handling Notes: β Gentle warming (β€37Β°C) and brief sonication may aid dissolution. β Avoid vigorous vortexing β may promote aggregation of aromatic residues. β Filter through 0.22 Β΅m PVDF for cell-based assays.
Post-Reconstitution Storage: β Short-term: 2β8Β°C for β€72 hours β Long-term: Aliquot and store at β80Β°C (β€3 freezeβthaw cycles)
π Recommended reconstitution accessories will be auto-added to cart β Adjust before checkout.
Ipamorelin Research Peptide: Key Investigational Pathways
Ipamorelin is actively studied for its selective ghrelin receptor agonism. Key research applications include:
GHSR-1a Receptor Pharmacology
Investigated in:
β HEK293 cells stably expressing hGHSR-1a for cAMP, IPβ, and Ξ²-arrestin bias profiling
β Competitive binding vs. ghrelin, GHRP-6, and Hexarelin (radioligand displacement)
β Receptor dimerisation (GHSR-1a:DRD2, BRET/FRET)
Selective GH Secretion Dynamics
Explored via:
β Primary rat pituitary cell cultures (GH ELISA, 10-min sampling; no ACTH/cortisol rise)
β Hypophyseal portal blood sampling in conscious rodents (GH pulse amplitude/frequency)
β Co-stimulation with GHRH analogues (synergy vs. additivity)
Anabolic & Metabolic Signalling
Studied in:
β C2C12 myotubes (IGF-1 secretion, Akt/mTOR phosphorylation, no ERK overactivation)
β Primary hepatocytes (IGF-1, ALS expression)
β DIO murine models (lean mass accretion, glucose tolerance)
Receptor Desensitisation & Bias
Evaluated in:
β Chronic vs. pulsatile dosing (GH pulse recovery kinetics)
β GRK2/3 recruitment (NanoBiT)
β cAMP vs. Ξ²-arrestin bias index vs. ghrelin (TRUPATH platform)
β οΈ All accessories (syringes, filters, vials) are for laboratory use only β not medical devices.
Why Order Ipamorelin from NovaVitality?
π¬ Structural validation: Every lot includes a CoA
π Research-first ethos: No βHGH releaserβ or performance claims β full support for receptor bias studies
π‘οΈ RUO integrity: Meets MHRA GMP Guide, FDA 21 CFR 1271, EU Annex 1 expectations
π¬ Expert support: Get help with bias factor calculation, pituitary cell culture, or GH pulse assay design
Legal and Safety Information
NovaVitality supplies Ipamorelin strictly for laboratory research, assay development, and educational purposes (RUO).
β This product is not approved by the MHRA, FDA, EMA, or any regulatory authority for: β Human use β Veterinary use β Diagnostic, therapeutic, or performance-enhancement use
β οΈ Critical Responsibilities for Researchers: β Use only under approved institutional biosafety protocols β Comply with local ethics oversight (e.g., AWERB for in vivo work) β Maintain full chain-of-custody documentation β Do not compound, dispense, or administer to living subjects
π NovaVitality disclaims all liability for unauthorised or off-label use. By purchasing, you affirm compliance with all applicable laws and institutional policies.
Ready to Advance Ghrelin Receptor & GH Pulse Research?
