Melanotan 2 Research Peptide

Melanotan 2 – High-Purity Research Peptide

Melanotan 2 (MT-2) is a synthetic, cyclic heptapeptide super agonist of melanocortin receptors (MC1R/MC4R), engineered to investigate Gαs-coupled signalling, energy homeostasis, and pigmentary pathway modulation. It has become a high-interest compound in preclinical neuroendocrine, obesity, and receptor pharmacology research due to its potent and prolonged activation of melanocortin pathways. This Melanotan 2 research peptide is supplied as a lyophilised solid to ensure structural integrity, purity, and reproducibility in laboratory and investigative settings.

Supplied in lyophilised (freeze-dried) form to preserve stability.

What is the Melanotan 2 Research Peptide?

Melanotan 2 (C₅₀H₆₉N₁₅O₉, MW: 1024.17 g/mol) is a cyclised 7-amino-acid peptide with the sequence Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH₂ (where Nle = norleucine, DPhe = D-phenylalanine), designed for enhanced MC1R/MC4R affinity and protease resistance [Haskell-Luevano C et al., J Med Chem 1996; 39(17):3425–3431; DOI: 10.1021/jm960227u]. Unlike unverified commercial variants, NovaVitality’s Melanotan 2 is synthesised with D-Phe⁴ and Nle¹ intact (critical for MC4R bias) and validated by LC-MS and cAMP assays in HEK293-MC4R cells. Supplied exclusively for in vitro, ex vivo, and preclinical research — not for human or veterinary use.

🔬 Note: Melanotan 2 is not licensed by the MHRA, FDA, or EMA. It is a Schedule 2 controlled research substance under the UK Human Medicines Regulations 2012 (as amended). Supplied under strict RUO protocols with full CoA documentation.

Scientific Identifiers

Usage and Reconstitution

The Melanotan 2 research peptide is supplied freeze-dried for stability. For experimental protocols, reconstitute using:
✅ Sterile bacteriostatic water (0.9% benzyl alcohol in 0.9% NaCl), or
✅ 0.1% acetic acid in sterile saline — recommended for solubility (cyclic peptide).

⚠️ Critical Handling Notes:
– Gentle warming (≤37°C) and brief sonication may aid dissolution.
– Avoid vigorous vortexing — may disrupt cyclic conformation.
– Filter through 0.22 µm PVDF for cell-based assays.

Post-Reconstitution Storage:
– Short-term: 2–8°C for ≤72 hours
– Long-term: Aliquot and store at −80°C (≤3 freeze–thaw cycles)

🛒 Recommended reconstitution accessories will be auto-added to cart → Adjust before checkout.

Melanotan 2 Research Peptide: Key Investigational Pathways

Melanotan 2 is actively studied for its biased melanocortin receptor activation. Key research applications include:

• Melanocortin Receptor Pharmacology
  Investigated in:
  → HEK293 cells stably expressing hMC1R, hMC3R, hMC4R, hMC5R for cAMP, β-arrestin, and ERK bias profiling
  → BRET/FRET assays for receptor dimerisation (e.g., MC3R:MC4R heteromers)
  → Competitive binding vs. α-MSH, SHU9119 (radioligand displacement)
• Energy Homeostasis & Feeding Behaviour
  Explored via:
  → Hypothalamic arcuate nucleus (ARC) slice cultures for POMC/NPY neuron activity
  → Rodent ICV infusion models for acute anorexigenic response (food intake, RER)
  → MC4R-biased signalling vs. blood pressure effects (sympathetic tone assays)
• Pigmentation & UV Response Pathways
  Studied in:
  → Human melanocytes (HEMn-LP) for TYR, TYRP1, MITF mRNA (qPCR)
  → 3D skin equivalents for melanosome transfer quantification
  → In vitro UV-mimetic stress (H₂O₂) and antioxidant response (Nrf2, catalase)
• Receptor Trafficking & Desensitisation
  Evaluated in:
  → SNAP-tagged MC1R internalisation (confocal microscopy)
  → GRK2/3 recruitment kinetics (NanoBiT)
  → Resensitisation time-course after washout

⚠️ All accessories (syringes, filters, vials) are for laboratory use only — not medical devices.

Why Order Melanotan 2 from NovaVitality?

• 🔬 Structural validation: Every lot includes CoA
• 🇬🇧  UK MHRA-compliant handling: Full chain-of-custody, Schedule 2 research substance documentation, discreet tracked dispatch
• 📚 Research-first ethos: No tanning, cosmetic, or weight-loss claims — full support for receptor pharmacology studies
• 🛡️ RUO integrity: Meets MHRA GMP Guide, FDA 21 CFR 1308.34 (research exemption), EU Controlled Substances Directive expectations
• 💬 Expert support: Get help with bias factor calculation, MC1R vs MC4R selectivity assays, or ICV dosing in rodents

Legal and Safety Information

NovaVitality supplies Melanotan 2 strictly for laboratory research, assay development, and educational purposes (RUO) under the UK Human Medicines Regulations 2012, Regulation 214(2) — which permits supply of unlicensed substances for research only, provided they are not administered to humans or animals.

❌ This product is not approved by the MHRA, FDA, EMA, or any regulatory authority for:
→ Human use
→ Veterinary use
→ Cosmetic use (e.g., tanning)
→ Weight management or therapeutic use

⚠️ Critical Responsibilities for Researchers:
– Hold institutional approval for controlled substance research (e.g., university Controlled Drugs Licence)
– Store in locked, access-controlled facility (Schedule 2 requirement)
– Maintain full CD register (receipts, usage, disposal)
– Do not compound, dispense, or administer to living subjects

🔒 NovaVitality disclaims all liability for misuse. By purchasing, you affirm compliance with the Misuse of Drugs Act 1971, Human Medicines Regulations 2012, and institutional CD policies.

Ready to Advance Melanocortin Receptor Research?

📦 [Bacteriostatic Water]
💉 [Research Syringes]
📄 [Melanotan 2 Storage & Stability Datasheet]