MOTS-c Research Peptide (10mg)

Name: MOTS-c Research Peptide (10mg) | RUO | NovaVitality
SKU: NV-MOTSC-10
Price: 20.00 GBP
Availability: InStock

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a bioactive mitochondrial-derived peptide, endogenously encoded within the mitochondrial genome. It has gained significant research interest for its role in metabolic regulation, cellular stress response, and age-related physiological pathways. This MOTS-c research peptide is supplied as a lyophilized (freeze-dried) solid to ensure stability, purity, and reproducibility in laboratory settings.

What is the the MOTS-c research peptide?

MOTS-c is a 16-amino-acid peptide (sequence: Met-Arg-Trp-Gln-Glu-Asn-Gln-Ala-Arg-Gly-Gly-Leu-Gly-Leu-Leu-Gly) first identified in 2015 as a regulator of metabolic homeostasis [Lee et al., Cell Metabolism (2015), DOI:10.1016/j.cmet.2015.02.005]. Unlike nuclear-encoded peptides, MOTS-c is transcribed from the mitochondrial 12S rRNA region and functions as a signalling molecule that modulates insulin sensitivity, glucose metabolism, and adaptive responses to metabolic stress. Research suggests it may act via the folate cycle and AMPK pathway to influence energy balance and cellular resilience. As with all NovaVitality products, this **MOTS-c research peptide** is supplied exclusively for *in vitro* and preclinical laboratory research use — not for human or veterinary use.

Scientific Identifiers

Product Name: MOTS-c 10mg
Catalogue Number: NV-MOTSC-10
CAS Number: Not yet assigned (peptide under active research; no official CAS as of 2025)
Molecular Formula: C₇₈H₁₂₈N₂₄O₂₅S
Molecular Weight: 1724.03 g/mol
Form: Lyophilized Solid
Storage: Store at −20°C, protected from light and moisture. Desiccate upon opening.
Unit Size: 10mg

Usage and Reconstitution

The MOTS-c research peptide is provided in freeze-dried form for optimal long-term stability. For laboratory research purposes, reconstitute using sterile bacteriostatic water (0.9% benzyl alcohol in saline) or acetic acid/saline buffers (e.g., 0.1% acetic acid in 0.9% NaCl), depending on experimental requirements and solubility protocols.

⚠️ Note: the MOTS-c research peptide may exhibit limited solubility in pure water; mild acidification (pH ~4–5) often improves dissolution. Avoid vortexing vigorously — gentle pipetting or brief sonication in a cold bath is recommended.

Once reconstituted:

Aliquot to avoid repeated freeze–thaw cycles
Store short-term at 2–8°C (≤7 days)
For long-term storage, freeze at −80°C

For detailed guidance, refer to our [Reconstitution & Handling Guide for Peptide Researchers].

You will require Bacteriostatic water & Syringes.

Automatically added to the cart will be:

✅ x1 1mL of Bacteriostatic Water
✅ x1 1mL fixed-needle syringes

→ Please add or remove items before finalising your purchase.

MOTS-c Research Peptide: Key Investigational Pathways

MOTS-c is under active investigation in cellular and preclinical models for its role in mitochondrial-nuclear crosstalk and metabolic adaptation. Key areas of scientific inquiry include:

Metabolic Regulation – Studied in skeletal muscle and adipocyte cell models for its effects on glucose uptake, insulin sensitivity, and AMPK activation.
Age-Related Physiology – Explored in murine aging models for its potential to mitigate age-dependent metabolic decline and improve physical performance.
Cellular Stress Response – Investigated in oxidative stress and ER stress assays, where MOTS-c appears to modulate redox balance and proteostasis pathways.
Exercise Mimetic Signalling – Evaluated as a candidate “exercise-induced myokine” in studies examining endurance, mitochondrial biogenesis, and fibre-type switching.

All accessories (e.g., vials, syringes, pens, filters) are classified as laboratory handling tools for research-grade compounds only. They are not medical devices and must not be used in human or animal administration.

Why Order MOTS-c from NovaVitality?

🔬 Each batch of MOTS-c research peptide is backed up by a CoA (Certificate of Analysis) available upon request
🇬🇧 Fast, tracked UK delivery — discreet & secure packaging
📚 Research-first ethos: no marketing claims, no consumer targeting
🛡️ Fully compliant with MHRA, FDA (21 CFR 1271), and EU regulatory expectations for RUO materials
💬 Dedicated scientific support for protocol design and solubility questions

Legal and Safety Information

NovaVitality supplies MOTS-c strictly for laboratory research and educational use only (RUO). This product is not approved by any regulatory agency (including the FDA, EMA, or MHRA) for human or veterinary therapeutic, diagnostic, or clinical applications. It is not a drug, supplement, or cosmetic.

⚠️ Important:

Do not self-administer or use in humans/animals.
Use only in accordance with institutional biosafety guidelines and local legislation.
Researchers are responsible for ensuring ethical oversight (e.g., IACUC/IRB approval where applicable).

NovaVitality disclaims all liability for misuse, improper handling, or off-label application.