PT-141 Research Peptide (10mg)

PT-141 Research Peptide (10mg)

PT-141 research peptide is a synthetic, cyclic melanocortin receptor agonist supplied as a lyophilised solid for stability and reproducibility in laboratory research. It is studied in models of neurobehavioral signalling, appetite regulation, and MC3R/MC4R activation — intended strictly for research use only.

What is the PT-141 Research Peptide?

PT-141 a cyclic melanocortin receptor agonist is a synthetic, cyclic heptapeptide and potent melanocortin receptor agonist, selectively targeting MC3R and MC4R. First characterised in studies of central melanocortin signalling [Haskell-Luevano et al., J Med Chem (1996), DOI:10.1021/jm960222h], this PT-141 research peptide is supplied as a lyophilised solid for stability and reproducibility in preclinical and in vitro research — not for human or veterinary use.

Unlike clinical formulations, NovaVitality’s PT-141 is intended exclusively for laboratory investigation of neuropeptide pathways, reward circuitry, and melanocortin-mediated physiology.

Scientific Identifiers

• Product Name: PT-141 Research Peptide
• Catalogue Number: NV-PT141-10
• CAS Number: 189691-06-3
• Molecular Formula: C₅₀H₆₈N₁₄O₁₀
• Molecular Weight: 1025.2 g/mol
• Peptide Sequence: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH
• Form: Lyophilised Solid
• Storage: Store at −20°C, desiccated, protected from light
• Unit Size: 10mg

Usage and Reconstitution

The PT-141 research peptide is provided freeze-dried for long-term stability. For laboratory protocols, reconstitute using sterile bacteriostatic water (0.9% benzyl alcohol in saline) or 0.1% acetic acid in saline, depending on solubility and assay compatibility.

⚠️ Note: PT-141 may require gentle warming (≤30°C) and slow mixing for complete dissolution. Avoid vortexing to prevent aggregation of the cyclic structure.

Once reconstituted:

• Aliquot to avoid repeated freeze–thaw cycles
• Store short-term at 2–8°C (≤72 hours)
• For long-term storage: −80°C

For full guidance, refer to our [Peptide Reconstitution Protocol].

PT-141 Research Peptide: Key Investigational Pathways 

PT-141 is actively studied for its role in central melanocortin modulation. Key research areas include:

• Melanocortin Receptor Signalling – Investigated in hypothalamic and limbic cell models for MC3R/MC4R activation, energy homeostasis, and satiety pathways.
• Neurobehavioral Mechanisms – Explored in rodent models of motivation, sexual behaviour, and reward circuitry (e.g., ventral tegmental area dopamine modulation).
• Neuroendocrine & Stress Response – Evaluated for interactions with CRH, ACTH, and HPA-axis regulation under controlled experimental conditions.
• Inflammatory Modulation – Studied in microglial and macrophage assays for melanocortin-mediated cytokine regulation (e.g., TNF-α, IL-6 suppression).

All accessories (syringes, vials, filters) are laboratory handling tools only — not medical devices.

Why Order PT-141 from NovaVitality?

• 🔬 Batch-certified: Each PT-141 research peptide lot is backed up by a CoA
• 🇬🇧   Fast UK dispatch — tracked, discreet, next-day available
• 📚 Research-first: Zero consumer marketing; technical support included
• 🛡️ RUO-compliant: Meets MHRA, FDA 21 CFR 1271, and EU expectations
• 💬 Protocol guidance: Get help with solubility, CNS delivery models, or receptor assays

Legal and Safety Information

NovaVitality supplies PT-141 strictly for laboratory research and educational use only (RUO). This product is not approved by the FDA, EMA, or MHRA for human or veterinary use. It is not a drug, supplement, or cosmetic.

⚠️ Critical:

• Do not administer to humans or animals
• Use only under institutional biosafety/ethics approval (e.g., IACUC/IRB)
• Researchers are solely responsible for compliance with local regulations

NovaVitality disclaims all liability for misuse, improper handling, or off-label application.

Ready to Advance Your Melanocortin or Neurobehavioral Research?

📦 [Order Bacteriostatic Water]
💉 [Order Research-Grade Syringes]
📄 [PT-141 Handling & Storage Protocol]