Retatrutide Research Peptide (10mg, 20mg, 30mg, 40mg)

Retatrutide – High-Purity Research Peptide

Retatrutide is a synthetic, triple GLP-1/GIP/GCGR receptor agonist peptide, engineered to investigate multi-incretin modulation of metabolic homeostasis. It has emerged as a high-priority compound in preclinical obesity and metabolic disease research, owing to its unprecedented efficacy in reducing body weight and improving insulin sensitivity via synergistic receptor activation. This Retatrutide research peptide is supplied as a lyophilised solid to ensure stability, purity, and reproducibility in laboratory and investigative settings.

Supplied in lyophilised (freeze-dried) form to preserve stability.

What is the Retatrutide Research Peptide?

Retatrutide (C₁₉₈H₃₀₆N₅₀O₅₈S₁, MW: ~4381.0 g/mol) is a 32-amino-acid peptide designed to co-activate glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCGR) receptors with balanced potency [Jastreboff et al., N Engl J Med 2023; DOI: 10.1056/NEJMoa2301972]. Unlike clinical formulations (which remain investigational), the Retatrutide research peptide from NovaVitality is provided exclusively for in vitro, ex vivo, and preclinical research — not for human or veterinary use.

🔬 Note: Retatrutide is not yet licensed by the MHRA, FDA, or EMA. It is supplied under strict RUO (Research Use Only) protocols.

Scientific Identifiers

Usage and Reconstitution

The Retatrutide research peptide is supplied freeze-dried for extended shelf life and stability. For experimental protocols, reconstitute using:
✅ Sterile bacteriostatic water (0.9% benzyl alcohol in 0.9% NaCl), or
✅ 0.1% acetic acid in sterile saline (recommended for improved solubility of GCGR-targeting domains).

⚠️ Critical Handling Notes:
– Gentle warming (≤37°C) and brief low-power sonication may be required for complete dissolution.
– Avoid vigorous vortexing or pipetting — triple-agonist peptides are prone to aggregation and fibril formation.
– Filter through a 0.22 µm PVDF syringe filter post-reconstitution for cell-based assays.

Post-Reconstitution Storage:
– Short-term: 2–8°C for ≤72 hours
– Long-term: Aliquot and store at −80°C (≤3 freeze–thaw cycles recommended)

📌 For step-by-step guidance, download our [Retatrutide Reconstitution & Handling Protocol].

🛒 Recommended reconstitution accessories will be auto-added to cart → Adjust before checkout.

Retatrutide Research Peptide: Key Investigational Pathways

Retatrutide is actively studied for its tripartite receptor engagement, enabling novel insights into energy regulation beyond dual-agonist models. Key research applications include:

• Integrated Metabolic Signalling
  Investigated in primary hepatocytes, adipocytes, and myotubes for effects on:
  → Lipolysis & fatty acid oxidation (GCGR-driven)
  → Insulin sensitisation & glucose uptake (GIP/GLP-1 synergy)
  → Hepatic gluconeogenesis suppression
• Central Appetite Regulation
  Explored in hypothalamic slice cultures and ex vivo ARC nucleus models for modulation of:
  → POMC/CART activation
  → NPY/AgRP suppression
  → GLP-1R/GCGR co-localisation in NTS neurons
• Triple-Receptor Crosstalk & Bias
  Studied via:
  → BRET/FRET assays for real-time receptor dimerisation (e.g., GLP-1R:GCGR heteromers)
  → β-arrestin recruitment vs. cAMP bias profiling
  → Endosomal signalling kinetics (sustained vs. transient activation)
• Gut–Brain Axis & Incretin Amplification
  Evaluated in enteroendocrine (L/K-cell) co-cultures for:
  → Amplified GLP-1/GIP co-secretion
  → Vagal afferent potentiation

⚠️ All accessories (syringes, filters, vials) are for laboratory use only — not medical devices.

Why Order Retatrutide from NovaVitality?

• 🔬 Batch-certified purity: Every lot includes full Certificate of Analysis (CoA) 
• 🇬🇧  UK-based & compliant: MHRA-aligned documentation, GMP-adjacent handling, discreet tracked shipping (next-day available)
• 📚 Research-first ethos: No consumer-facing claims — full technical & protocol support
• 🛡️ RUO integrity: Meets expectations under MHRA GMP Guide, FDA 21 CFR 1271, EU GMP Annex 1, and ISO 13485 handling standards
• 💬 Expert support: Get guidance on triple-agonist solubility, dose-response curves, in vivo study design, or receptor assay optimisation

Legal and Safety Information

NovaVitality supplies Retatrutide strictly for laboratory research, assay development, and educational purposes (RUO).

❌ This product is not approved by the MHRA, FDA, EMA, or any regulatory authority for:
→ Human use
→ Veterinary use
→ Diagnostic use
→ Therapeutic use

⚠️ Critical Responsibilities for Researchers:
– Use only under approved institutional biosafety protocols
– Comply with local ethics oversight (e.g., IACUC, AWERB, or IRB)
– Maintain full chain-of-custody documentation
– Do not compound, dispense, or administer to living subjects

🔒 NovaVitality disclaims all liability for unauthorised or off-label use. By purchasing, you affirm compliance with all applicable laws and institutional policies.

Ready to Explore Triple-Agonist Metabolic Research?

📦 [Bacteriostatic Water – 1-10 mL]
💉 [Research Syringes – 1 mL]
📄 [View: Retatrutide Storage & Stability Datasheet]