Selank Research Peptide

Selank – High-Purity Research Peptide

Selank is a synthetic, heptapeptide analogue of tuftsin, engineered to investigate immunomodulatory and neuromodulatory pathways, particularly GABAergic tone, cytokine regulation, and BDNF expression. It has become a high-interest compound in preclinical neuroscience, stress-response, and neuroinflammation research due to its anxiolytic-like effects in rodent models without sedation or dependence liability. This Selank research peptide is supplied as a lyophilised solid to ensure stability, purity, and reproducibility in laboratory and investigative settings.

Supplied in lyophilised (freeze-dried) form to preserve stability.

What is the Selank Research Peptide?

Selank (C₃₇H₅₃N₁₁O₉S, MW: 855.94 g/mol) is a 7-amino-acid peptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, modified with an N-terminal Thr-Lys-Pro extension and C-terminal amidation for enhanced stability and blood–brain barrier permeability [Ashmarin IP et al., Bull Exp Biol Med 2005; 140(4):447–451; DOI: 10.1007/s10517-005-0447-9]. Unlike unlicensed nootropic formulations, the Selank research peptide from NovaVitality is provided exclusively for in vitro, ex vivo, and preclinical research — not for human or veterinary use.

🔬 Note: Selank is registered in Russia as a prescription anxiolytic (Selank®), but this RUO material is unformulated, preservative-free, and intended solely for mechanistic neuroscience and immunology research.

Scientific Identifiers

Usage and Reconstitution

The Selank research peptide is supplied freeze-dried for stability. For experimental protocols, reconstitute using:
✅ Sterile bacteriostatic water (0.9% benzyl alcohol in 0.9% NaCl), or
✅ Sterile saline (0.9% NaCl) — preferred for in vivo CNS studies (minimises irritation).

⚠️ Critical Handling Notes:
– Highly soluble — typically dissolves fully with gentle swirling (no warming or sonication needed).
– Avoid acetic acid — may reduce stability in long-term storage (Pro-rich sequences are acid-labile).
– Filter through a 0.22 µm PVDF syringe filter for intranasal or ICV studies.

Post-Reconstitution Storage:
– Short-term: 2–8°C for ≤7 days
– Long-term: Aliquot and store at −80°C (≤5 freeze–thaw cycles tolerated — Selank is highly stable in solution)

🛒 Recommended reconstitution accessories will be auto-added to cart → Adjust before checkout.

Selank Research Peptide: Key Investigational Pathways

Selank is actively studied for its multimodal neuromodulatory and immunoregulatory effects. Key research applications include:

• GABAergic & Monoaminergic Modulation
  Investigated in:
  → Rat prefrontal cortex microdialysis for GABA, serotonin, and dopamine flux
  → Electrophysiology in hippocampal slices for GABAₐ receptor potentiation
  → BDNF/TrkB expression in neuronal cultures (Western blot, qPCR)
• Neuroinflammation & Cytokine Regulation
  Explored via:
  → LPS-challenged microglia (BV-2) for IL-6, TNF-α, IL-10 secretion (ELISA)
  → NF-κB nuclear translocation assays (immunofluorescence)
  → Transcriptomic profiling of stress-induced cytokine networks
• Stress Response & Anxiety-Like Behaviour
  Studied in:
  → Elevated plus maze (EPM) and open field test (OFT) in rodents (acute vs. chronic dosing)
  → HPA axis modulation (corticosterone, CRH, ACTH)
  → Fear conditioning and extinction paradigms
• Enzymatic Stability & BBB Penetration
  Evaluated in:
  → Human serum stability assays (HPLC half-life)
  → In vitro BBB models (hCMEC/D3 monolayers, Papp calculation)
  → MALDI-IMS for brain distribution mapping post-intranasal delivery

⚠️ All accessories (syringes, filters, vials) are for laboratory use only — not medical devices.

Why Order Selank from NovaVitality?

• 🔬 Batch-certified purity: Every lot includes full Certificate of Analysis (CoA)
• 🇬🇧  UK-based & compliant: MHRA-aligned documentation, GMP-adjacent handling, discreet tracked shipping (next-day available)
• 📚 Research-first ethos: No nootropic or cognitive-enhancement claims — full technical & protocol support
• 🛡️ RUO integrity: Meets expectations under MHRA GMP Guide, FDA 21 CFR 1271, EU GMP Annex 1
• 💬 Expert support: Get guidance on intranasal dosing, serum stability assays, or GABAₐ receptor binding protocols

Legal and Safety Information

NovaVitality supplies Selank strictly for laboratory research, assay development, and educational purposes (RUO).

❌ This product is not approved by the MHRA, FDA, EMA, or any regulatory authority for:
→ Human use
→ Veterinary use
→ Diagnostic use
→ Therapeutic, nootropic, or supplement use

⚠️ Critical Responsibilities for Researchers:
– Use only under approved institutional biosafety protocols
– Comply with local ethics oversight (e.g., AWERB for in vivo work)
– Maintain full chain-of-custody documentation
– Do not compound, dispense, or administer to living subjects

🔒 NovaVitality disclaims all liability for unauthorised or off-label use. By purchasing, you affirm compliance with all applicable laws and institutional policies.

Ready to Advance Neuromodulatory Pathway Research?

📦 [Bacteriostatic Water]
💉 [Research Syringes]
📄 [Selank Storage & Stability Datasheet]