Supplied for research purposes only. These peptides are laboratory reagents intended for qualified researchers and educational institutions. Not for human use, animal use, or clinical application.
TB-500 is a synthetic, 43-amino-acid fragment of Thymosin β4, engineered to investigate G-actin sequestration, cell migration, and tissue repair signalling pathways. It has become a pivotal compound in preclinical wound healing, musculoskeletal regeneration, and anti-fibrotic research due to its potent effects on cytoskeletal dynamics, angiogenesis, and inflammatory modulation. This TB-500 research peptide is supplied as a lyophilised solid to ensure structural integrity, purity, and reproducibility in laboratory and investigative settings.
Supplied in lyophilised (freeze-dried) form to preserve stability.
What is the TB-500 (Thymosin Beta-4) Research Peptide?
TB-500 (C₂₁₂H₃₄₆N₆₂O₆₆S₃, MW: 4963.37 g/mol) is the N-terminal 1–43 fragment of full-length Thymosin β4 (residues 1–43), with the sequence Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Ser-OH, preserving the critical LKKTET actin-binding domain and N-terminal acetylation for stability [Bock SC et al., J Biol Chem 1989; 264(8):4644–4649; DOI: 10.1016/S0021-9258(18)81679-8]. Unlike uncharacterised commercial variants, NovaVitality’s TB-500 is synthesised with Met⁶ intact and validated by LC-MS and pyrene-actin polymerisation assays. Supplied exclusively for in vitro, ex vivo, and preclinical research — not for human or veterinary use.
🔬 Note: TB-500 is not licensed by the MHRA, FDA, or EMA. It is supplied under strict RUO (Research Use Only) protocols. Full-length Thymosin β4 (CAS 77530-35-3) is distinct from this fragment.
Scientific Identifiers
Field
Value
Product Name
TB-500 (Thymosin Beta-4 Fragment) Research Peptide
The TB-500 research peptide is supplied freeze-dried for stability. For experimental protocols, reconstitute using: ✅ Sterile bacteriostatic water (0.9% benzyl alcohol in 0.9% NaCl), or ✅ 0.1% acetic acid in sterile saline — recommended for solubility (Lys-rich domain).
⚠️ Critical Handling Notes: – Gentle warming (≤37°C) and brief sonication may aid dissolution. – Avoid neutral/basic buffers (pH >7.0) — promotes aggregation due to Lys charge neutralisation. – Filter through 0.22 µm PVDF for cell-based assays.
Post-Reconstitution Storage: – Short-term: 2–8°C for ≤72 hours – Long-term: Aliquot and store at −80°C (≤3 freeze–thaw cycles)
🛒 Recommended reconstitution accessories will be auto-added to cart → Adjust before checkout.
TB-500 Research Peptide: Key Investigational Pathways
TB-500 is actively studied for its cytoskeletal and regenerative bioactivity. Key research applications include:
📚 Research-first ethos: No “regeneration” or “healing” claims — full support for mechanistic cytoskeletal studies
🛡️ RUO integrity: Meets MHRA GMP Guide, FDA 21 CFR 1271, EU Annex 1 expectations
💬 Expert support: Get help with actin assay setup, dosing in tendon models, or stability in culture media
Legal and Safety Information
NovaVitality supplies TB-500 strictly for laboratory research, assay development, and educational purposes (RUO).
❌ This product is not approved by the MHRA, FDA, EMA, or any regulatory authority for: → Human use → Veterinary use → Diagnostic, therapeutic, or cosmetic use
⚠️ Critical Responsibilities for Researchers: – Use only under approved institutional biosafety protocols – Comply with local ethics oversight (e.g., AWERB for in vivo work) – Maintain full chain-of-custody documentation – Do not compound, dispense, or administer to living subjects
🔒 NovaVitality disclaims all liability for unauthorised or off-label use. By purchasing, you affirm compliance with all applicable laws and institutional policies.
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